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Phosphodiesterase Type 5 Inhibitors: Mechanism of Action

A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a drug the helps the body’s natural response to sexual stimulus. The PDE5-based medicines are usually used to treat erectile dysfunction; however, they’ve been proven to work with a variety of serious issues: muscular dystrophy, fear of heights, several cardiovascular diseases and so on. The most well-known types of PDE5 drugs are:

  • Viagra,
  • Cialis,
  • Levitra.


Generally, PDE5 inhibitor provides help when it comes to one’s natural response to sexual stimulus, they block out the enzymes. Which, in turn, increased the blood flow to the penis during any kind of sexual activity. This, obviously, means that PDE5 inhibitors are not effective with no sexual stimulus. Contrary to popular belief, PDE5 drugs do not cause erections, they help your body’s response to “sexy” situations.

Adverse Effects

There are some adverse effects to be mindful of when using any kind of PDE5 inhibitor. As tadalis-sx helpfully points out, most of the side-effects appear to be dose-related. The most prevalent side-effects include: indigestion, headache, feeling dizzy, and rhinitis. There were other claimed side-effects, but they turned out to be nothing more than an elaborate smear campaign. In general, many adverse effects aren’t worrying/serious. According to the data from tadalis-sx.net, men almost never stop taking PDE5 because of the adverse effects.

When Not to Use PDE5 Inhibitors?

First and foremost, these types of pills shouldn’t be used with “nitrate” drugs that treat some kinds of cardiovascular diseases. That mostly has to do with the release of nitric oxide as a result of sexual stimulation. In general, if you have a heart issue that’s ongoing, you’d be better off consulting with your specialist before taking PDE5.

Things Not to Do

  • Don’t try to have sex too early or too late after taking the pill.
  • Don’t think you will just pop an erection for seemingly no reason.
  • Don’t eat a big meal before taking the pill.
  • Don’t drink alcohol.
  • Don’t let your anxiety take the best of you.

All of the above can seriously lessen the drug’s effectiveness. Some data from from different sources suggests that you can drink alcohol, but do not overdo it. Better stay on the safer side.